Thursday, May 31, 2012

Angels ace Weaver to DL with lower-back woes

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

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Liquiglide Could Fix Your Sticky Condiments Problems

Do you have a bunch of condiment bottles in the pantry sitting upside down so that you can get every last drop out? ?Do you worry about how much condiment you’re actually throwing away because you just can’t get the last of it out of the bottle? ?Sick of thumping that ketchup bottle and ending [...]

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Kleiner Perkins Adds Megan Quinn, Former Products Director At Square, As Newest Investment Partner

new-avatarMegan Quinn, the web exec who most recently served as the Director of Products at credit card processing tech firm Square, has joined Sand Hill Road venture capital firm Kleiner Perkins Caufield & Byers as an investment partner. The hire was announced by KPCB in a press release today.

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The horror in Syria, the cold realities of international action

Syria's civil war is horrific, with most of the crimes committed by the Assad regime and its supporters. This may lead to moral clarity, but not necessarily to international military action.

By Dan Murphy,?Staff writer / May 30, 2012

Jordanians and Syrian refugees take part in a demonstration against Syria's President Bashar al-Assad, and to protest against the killing of at least 108 people in the Syrian town of Houla last Friday, outside the Syrian embassy in Amman, Jordan, Wednesday, May 30.

Ali Jarekji/Reuters

Enlarge

Syria's Houla massacre last week was a war crime. This much is certain. After government shelling of Houla killed about 20 people there, a further 90 residents were hunted down in their homes and shops and then butchered, many of them children.?

Skip to next paragraph Dan Murphy

Staff writer

Dan Murphy is a staff writer for the Monitor's international desk, focused on the Middle East.

Recent posts

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The massacre has shifted the international picture, with the mass expulsion of Syrian diplomats from Britain, the US, France, and six other countries, slightly tougher talk from the United Nations officials working with special envoy Kofi Annan, and a burst of outrage from politicians around the world. Who was responsible? The activists and their supporters insist it was the Syrian Army itself, but there is not yet any hard evidence, only indications. Analysts who know the region well expect that the murders were carried out by shabiha, pro-government militiamen who work in concert with the military.

The cui bono reasoning of some on the anti-imperial left, who suggest the massacre was carried out by President Bashar al-Assad's opponents (since it makes his regime look so bad), should be dismissed as the logical contortion that it is. The Assad family has killed and tortured tens of thousands to retain power down the decades.

The slaughter yesterday, and the discovery today, of 13 bound men who were executed near Deir al-Zhour punctuate a reality that has been long apparent: UN special envoy Kofi Annan's "peace plan" for Syria is a failure, with Mr. Assad and his allies determined to hold on to power and survive. Assad emphasized that to Russian television a few weeks ago, complaining of a propaganda war against him, denying massacres of civilians and concluding that "the main thing is to win in real life."?

But what is to be done? This is where all certainty evaporates, and a landscape of imperfect, dangerous choices reveals itself.

Humanitarian interventionists insist the time has come for military pressure to be exerted from the outside and they're finding allies in major capitals. French President Fran?ois Hollande fumed, "it is not possible to allow Bashar al-Assad's regime to massacre its own people," though he said military action would require UN Security Council approval.?

Presidential hopeful Mitt Romney, who last July criticized President Barack Obama for supporting the NATO mission that helped drive Libya's Muammar Qaddafi from power (Mr. Romney fretted about "who?s going to own Libya if we get rid of the government there??) wants arms shipments to the rebels and "more assertive measures to end the Assad regime." He blamed President Obama for "lack of leadership [that] has resulted in a policy of paralysis that has watched Assad slaughter 10,000 individuals."

He's not alone. The Washington Post's hawkish editorial page is on board too, sort of. In an editorial largely dedicated to ridiculing Mr. Annan's failed effort ("feckless," "one of the most costly diplomatic failures in UN history") it calls for Obama to do, well, something. The paper insists the time has come for US "leadership," but through what means, and exactly to where, it doesn't say.

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Wednesday, May 30, 2012

It Gets Better (talking-points-memo)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

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The REMARK checklist explained: How to use guidelines on reporting tumor marker prognostic studies

The REMARK checklist explained: How to use guidelines on reporting tumor marker prognostic studies [ Back to EurekAlert! ] Public release date: 29-May-2012
[ | E-mail | Share Share ]

Contact: Clare Weaver
press@plos.org
44-122-344-2834
Public Library of Science

In an "elaboration and explanation" of the REMARK (Reporting Recommendations for Tumor Marker Prognostic Studies) checklist, Doug Altman of the University of Oxford, UK and colleagues provide a detailed reference for authors on important issues to consider when designing, conducting, analyzing and reporting tumor marker prognostic studies. Writing in this week's PLoS Medicine (and co-published in BMC Medicine) the authors explain the checklist items in detail and illustrate each one with published examples of good reporting.

In this Guidelines and Guidance article, the authors say: "Physicians seek information about tumor markers to inform therapeutic decisions for individual patients... In order for information about the utility of tumor markers to be appropriately evaluated, the methods used to study the markers and the results generated must be fully reported."

Incomplete reporting of prognostic marker studies in cancer and other specialities is a regrettably frequent occurrence. The REMARK recommendations (published in 2005) provide criteria for assessing the completeness of reporting of such studies, though it is important to highlight that REMARK should not be used to dictate standards for the quality of research. Instead, it is intended to be a useful tool to assist with assembling the necessary information for judging the quality and relevance of research. Altman and colleagues aim to educate users of the REMARK checklist, leading to more effective implementation of its recommendations, and as a result, more consistent, high quality reporting of tumor marker studies.

The authors comment: "Good reporting reveals the strengths and weaknesses of a study and facilitates sound interpretation and application of study results. The REMARK recommendations may also aid in planning new studies, and may be helpful for peer reviewers and editors in their evaluation of manuscripts."

###

Funding: No direct funding was received for this study. DGA is supported by a grant from Cancer Research UK (C5529). The other authors were personally salaried by their institutions during the period of writing (though no specific salary was set aside or given for the writing of this paper). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: All authors declare no competing interests.

Citation: Altman DG, McShane LM, Sauerbrei W, Taube SE (2012) Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): Explanation and Elaboration. PLoS Med 9(5): e1001216. doi:10.1371/journal.pmed.1001216

CONTACT:
Doug Altman
Centre for Statistics in Medicine
University of Oxford
Oxford
United Kingdom
44 1865 284401
doug.altman@csm.ox.ac.uk



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


The REMARK checklist explained: How to use guidelines on reporting tumor marker prognostic studies [ Back to EurekAlert! ] Public release date: 29-May-2012
[ | E-mail | Share Share ]

Contact: Clare Weaver
press@plos.org
44-122-344-2834
Public Library of Science

In an "elaboration and explanation" of the REMARK (Reporting Recommendations for Tumor Marker Prognostic Studies) checklist, Doug Altman of the University of Oxford, UK and colleagues provide a detailed reference for authors on important issues to consider when designing, conducting, analyzing and reporting tumor marker prognostic studies. Writing in this week's PLoS Medicine (and co-published in BMC Medicine) the authors explain the checklist items in detail and illustrate each one with published examples of good reporting.

In this Guidelines and Guidance article, the authors say: "Physicians seek information about tumor markers to inform therapeutic decisions for individual patients... In order for information about the utility of tumor markers to be appropriately evaluated, the methods used to study the markers and the results generated must be fully reported."

Incomplete reporting of prognostic marker studies in cancer and other specialities is a regrettably frequent occurrence. The REMARK recommendations (published in 2005) provide criteria for assessing the completeness of reporting of such studies, though it is important to highlight that REMARK should not be used to dictate standards for the quality of research. Instead, it is intended to be a useful tool to assist with assembling the necessary information for judging the quality and relevance of research. Altman and colleagues aim to educate users of the REMARK checklist, leading to more effective implementation of its recommendations, and as a result, more consistent, high quality reporting of tumor marker studies.

The authors comment: "Good reporting reveals the strengths and weaknesses of a study and facilitates sound interpretation and application of study results. The REMARK recommendations may also aid in planning new studies, and may be helpful for peer reviewers and editors in their evaluation of manuscripts."

###

Funding: No direct funding was received for this study. DGA is supported by a grant from Cancer Research UK (C5529). The other authors were personally salaried by their institutions during the period of writing (though no specific salary was set aside or given for the writing of this paper). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: All authors declare no competing interests.

Citation: Altman DG, McShane LM, Sauerbrei W, Taube SE (2012) Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): Explanation and Elaboration. PLoS Med 9(5): e1001216. doi:10.1371/journal.pmed.1001216

CONTACT:
Doug Altman
Centre for Statistics in Medicine
University of Oxford
Oxford
United Kingdom
44 1865 284401
doug.altman@csm.ox.ac.uk



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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How to Have a Successful Product Launch | InternetResourcesA-Z ...


When you are thinking about bringing a new product to the Internet market, you know that there will be a lot of work that goes into making it successful. The main goal is to hit the market with a big impact, get some serious visibility for your product out there, or an entire group of products. The strategies you use for this are also translatable to any current campaign you have as well, and they may actually help you breathe some new life into any stagnant products you have and bring more customers on board. But you must remember that a lot of innovation needs to go into this new product, coupled with effective strategy building to make your own unique place in the market. There are really only two possible results when you bring a product to market, you can either experienced amazing success or you will fade into the sea of similar products on the market. This article will dole out advice that can be used to ensure a successful product launch and will help you learn how to benefit the most from your upcoming launch. We hope you are enjoying reading about what may be new ideas for your marketing campaigns, so be sure to seriously consider the possibilities. Yes, it does take a certain amount of psychological risk to consider something you make thing just does not work. One thing you can easily do is test review of Exit Plan Profits on a small scale, and that is another approach we tell people to try - just do a small test and decide. Only you know, in the end, what is best for your business; even though we have encouraged you to have an open mind and test.

If you do lose money on some lame method that does not work, then you have learned a valuable lesson and just move on. There really are a lot of people, we assume based on what we have read, who just blindly buy things they think will work great and maybe never even try them. Online marketers who are impatient or simply do not know are at the greatest risk. Always seek to validate anything you read, and that is they only path to protecting your self. It is just like locking your car every time you park it, maybe it will never prevent something but one day years from now it could.

One of the biggest days in the life cycle of any product will be its launch day. You want to spend as much time as you can planning every aspect of this day. If you lack on the planning part, then your product launch might go in the wrong direction and not generate as much aplomb as it should. No one wants to go through the hard work of developing a product only to see it fail at launch. The best way to do effective planning is to make sure every little detail is in place, tried and tested before the big day. Many product launches have some sort of technical glitch that occurs, so you need to think about how you might address this in advance.

Your preparation is going to determine how well your product is received by the intended audience. It wouldn't hurt to gather some people who will offer their opinion or can show you some ways to turn the moment into an income generating event. Also, when you are preparing for a launch, you need to identify your target market in the most accurate manner. Don't just look into potential buyers but instead laser target your market for the best results. This is one of the thing that causes the most problems for new launches, they never figure out what market they are trying to do business with.

One of the methods that is commonly used throughout the industry is to have a massive affiliate network in place for launch day, but you may want to consider if this strategy is right for you. There is some sense in the practice of using the affiliates to sell your new product and it can generate lots of sales, but there are other strategies that you can think about too. One great way to increase interest is to release the product preliminarily to your existing customer base so that you are rewarding your customers for loyalty. One month down the line, you might be open to the option of having affiliates bring you the sales. The important thing is to make sure that you can differentiate yourself from your competition.

Before you do anything, you should have a solid plan on what your marketing strategy is going to be, and have it written down. If you go about launching your product without a solid plan in place, this leaves too much room for error, and the errors that can occur can mean the demise for your product.

To conclude, it's easy to see why the product launch can make or break a business, and why the success of this day can mean huge earnings for the future. The results of your product's launch will furthermore make a way for improved sales going forward.



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Tuesday, May 29, 2012

Wing of the Matigara Zonal Income Tax office in ... - Sikkim NOW!

Sikkim NOW!: Sikkim applicants now required to approach Matigara IT office for IT Exemption Certificates VISHNU NEOPANEY GANGTOK, 27 May: Residents of Sikkim who are exempted under the Income Tax Act, Section 27 AAA, will have to henceforth approach the Tax Deduction at Source (TDR) Wing of the Matigara Zonal Income Tax office in Siliguri for IT Exemption Certificates. The Regional Office of the IT Department at Kolkata, in its meeting with regional heads and Officers In-charge of different districts [Malda, Siliguri, Jalpaiguri, Darjeeling, Kalimpong] including Sikkim, on 14 May directed the Gangtok office not to issue any more IT Exemption Certificates since this power did not fall in its jurisdiction. Till now, the Aayakar Bhawan at Gangtok, established in 2008, had been issuing the IT exemption certificates. The 14 May meeting resolved that the Gangtok office is mandated to handle only the revenue section for IT assessment. Other tasks like TDS directions and Tax refunds are not delegated to it. So far, because Direct Tax laws were new to Sikkim, the Gangtok IT office was also issuing IT exemption certificates [to Sikkim Subjects and their descendents], for the convenience of the people here, on the verbal direction of senior officials. Direct Tax Laws came into force in Sikkim on 21 June, 2008 and the Income Tax Department is represented here by an Assistant Income Tax Officer. The Ministry of Finance, Tax Department, has set up an office here to manage IT returns in Sikkim. Sikkim is in a transitional phase in terms of Direct Taxes and the Ministry of Finance and Regional IT Office at Kolkata have not yet felt it necessary to set up the other wings in Sikkim. As a result, a large number of people are still unaware of Direct Tax norms like filing of returns, claims and TDS or the importance of PAN and TIN numbers. The Gangtok office has already begun directing applicants the TDS wing of the Zonal Matigara Office, Siliguri for IT exemption certificates. IT officials in Siliguri informed NOW! over the phone that after receiving the exemption application from applicants, the Zonal Office will forward the applications for Regional Office verification and after receiving the IT clearance from Gangtok office, the exemption will be granted by the Regional Office if found appropriate. What is required now for the convenience of the people is for the State Government to approach the Ministry of Finance seeking establishment of other wings of the IT Department in Sikkim.

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Wellness Marketing Contractor - Weight loss Classifieds

Free Classifieds Health & Fitness Weight Loss

Our team is currently looking to expand and recruiting new team members to work part time and full time as Internet Wellness Marketing Contractors. We are a committed and successful team of women marketing on the Internet from home. Take a closer look at the Women?s Dream Team and learn how you can work as a Wellness Contractor on your terms.

Job Responsibilities:
Develop targeted marketing campaigns
Manage and implement field marketing tactics
Implement tools and resources to streamline work processes and ensure efficiency
Craft and edit copy for multiple platforms directed for consumer and B2B markets
Ensure consistency of messages and branding, and evaluate accuracy and effectiveness among all forms of print and electronic communications
Work closely with team members to support team initiatives
Solely responsible for managing projects
Attend remote meetings online regularly

Desired Skills & Experience:
Must be motivated and self-disciplined
Strong organizational, interpersonal, project management and written/verbal communication skills
Capacity to adapt to a changing environment
Leadership and mentoring experience highly desired
Minimal experience in health, fitness, marketing, education or training a plus, but not required
Must be coachable and open to learning new trends of marketing online

This position is home-based and can be performed anywhere in the US or Canada.
High School Diploma required
Computer with Internet access required

Please visit www.WomensDreamTeam.com/SuccessSeeker to request more information by clicking on ?CONTACT US NOW.?

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Sharing China?s anti-desertification experiences with Africa (Paper.li / China Daily)

Read at :

http://paper.li/f-1318161034?utm_source=subscription&utm_medium=email&utm_campaign=paper_sub

Africa learns from China in anti-desertification

CHIFENG, Inner Mongolia ? The United Nations Convention to Combat Decertification (UNCCD) will help share China?s experiences in controlling decertification with Africa, said an official with the UNCCD on Friday in Chifeng city, in North China?s Inner Mongolia autonomous region.

China?s ecosystems, particularly those in plateau and semi-plateau regions, are very much similar to those in many African countries affected by land decertification and degradation, said Dr Mansour N? Diaye, Chef de Cabinet of the UNCCD Secretariat.

He made the remarks at the end of a three-day Media Workshop on Decertification, Land Degradation and Drought in Asia, which attracted journalists and officials from over 40 countries in Asia and Africa.

Attendees to the workshop visited the anti-decertification projects run by local governments and interviewed farmers working in the field.

He said the UNCCD is looking for projects that can be easily replicated in other countries, and that make differences to people?s living conditions.

(continued)

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About Willem Van Cotthem

Honorary Professor of Botany, University of Ghent (Belgium). Scientific Consultant for Desertification and Sustainable Development. This entry was posted in Desertification. Bookmark the permalink.

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Obama vows to protect benefits for veterans

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Search Engine Optimization (SEO): An hour a day

The third edition of the bestselling guide to do-it-yourself SEOGetting seen on the first page of Search Engine Result Pages is crucial for businesses and online marketers. The search engine optimization to help improve the ranking of websites, and is often complex and confusing. This task-based, practical guide covers the concepts and trends, and outlines a strategy from day to day development, management and measurement of an effective SEO plan. Using tools that you can download and case histories to illustrate key points, it is ideal for busy merchants, business owners and others whose jobs are to improve Web site?

Search Engine Optimization (SEO): An Hour a Day

While word of mouth is a very effective tool when it comes to getting your business known, it is not expected to make you a millionaire overnight. Well, none actually can. However, there are ways on how to get to your goals much more quickly. One is by online business promotion. If you have been thinking of building an enterprise on the Internet, then this is a must-learn. Read on and discover its value from the SEO mastermind.

As you know, promotion has always been a major part of establishing a business. Some of the conventional methods like direct mails, press releases, and print ads have always greatly contributed to the success of a brand or a product. While these strategies remain comparatively useful, doing online promotion is proving to be more worth the resources of a business. If you wish to give it a try, here are some promotion tips that can come in handy:

Start a website? A website is a requisite in starting an online business. It will serve as the virtual store where you can showcase products or services. It?s where you are going to introduce them, market them, sell them, and make money from them. That said, it is crucial that you build a good website. Start with coming up with the right domain name. Something easy to recall would be very helpful so people will find and remember you without trouble.

Create excellent content? Of course, a good domain name can only be useful to an extent. If the content of your site is uninteresting, or worse, senseless, no one would want to linger there for long. Obviously, this will spell the failure of your efforts on online business promotion. So, enticing, sensible, and wise content should be your goal on a daily basis. Don?t forget to also provide your readers with clear and concise information about who you are and what you do. This will increase your audience?s interest in doing business with you.

Go for interactivity ? With building a site comes the responsibility of building relationships. Your aim is to have a steady group of followers because they too, will be your potential clients. However, this won?t happen unless you express willingness to interact with them. To do this, you have to make your site very open to everyone. Encourage readers to comment on your posts and answer questions if they have any. You should also prepare some brochures that can easily be downloaded to know more about the nature of your business as well as your goals.

Learn about SEO? Search Engine Optimization or SEO is the modern technique of increasing one?s visibility in the World Wide Web. It utilizes various methods so that a site can be known and visited by more people. This is helpful because the higher the traffic of a site becomes, the higher its profitability becomes too.

The internet has paved the way to a new structure of doing business. It?s absolutely useful and efficient; however, your success also largely depends on how much you know of the methodology and how far you are willing to exhaust it. With these tips on online business promotion, you can start planning how your enterprise is going to effectively move in the next months or so with the help of local Melbourne SEO services today.

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Sunday, May 27, 2012

New Insights into How DNA Mutations Lead to Cancer

Spontaneous changes in our genes can lead to cancer, if key genes involved in cell division are affected. New research is shedding new light on how mutations in our genetic material can combine to cause cancer.

Chromosomal deletions in DNA often involve just one of two gene copies inherited from either parent. But scientists haven?t known how a deletion in one gene from one parent, called a ?hemizygous? deletion, can contribute to cancer.

A research team led by Stephen Elledge, a professor in the Department of Genetics at Harvard Medical School, and his post-doctoral fellow Nicole Solimini, has now provided an answer. The most common hemizygous deletions in cancer, their research shows, involve a variety of tumor suppressing genes called STOP genes (suppressors of tumorigenesis and proliferation) that scatter randomly throughout the genome, but that sometimes cluster in the same place on a chromosome. And these clusters, said Elledge, who is also a professor of medicine at Brigham and Women?s Hospital, tend to be deleted as a group. ?Eliminating the cluster gives a bigger bang for the deletion buck,? he said.

This finding is especially interesting in light of the two-hit model of cancer formation, which holds that both copies of a recessive gene need to be inactivated to trigger a biological effect. Thus the loss of a single tumor suppressor copy should have little or no influence on tumor cell proliferation because the remaining copy located on the other chromosome is there to pick up the slack.

Elledge?s research points to a different hypothesis, namely that STOP genes in a hemizygous deletion aren?t recessive but are instead haploinsufficient, meaning that they depend on two copies to function normally. ?If a tumor suppressor is haploinsufficient, then a single gene copy lacks the potency needed to fully restrain tumorigenesis,? Elledge explained, who is also a Howard Hughes Medical Institute Investigator. ?So by removing clusters of haploinsufficient genes all at once, the cancer cell immediately propels its growth forward without having to wait for the other copies to also be lost.?

Angelika Amon, a professor of biology at the Massachusetts of Technology, said she?s surprised by the findings. ?We?ve known from a lot of human syndromes that haploinsufficiency is widespread in the development of complex multicellular organisms,? she said. ?But these data show it?s also critical for individual cells and cell proliferation.?

The results also offer a different take on the two-hit model in carcinogenesis, Amon said. Being remarkably unstable, cancer cells can delete gene copies at every turn of the corner. If the loss of a single tumor suppressor copy provides no survival advantage for the tumor, then the tumor has no incentive to retain the cell with that deletion. But if the loss of that copy boosts proliferation, then the probability of a second hit later is greatly increased. ?So haploinsufficiency is a way for the cancer cell to dramatically accelerate the acquisition of growth beneficial mutations,? Amon said.

In other words, all it takes is a 50 percent reduction in gene activity for a cancer cell to grow. ?That tells us it?s a lot easier to get cancer than we might have hoped,? Amon said.

According to Elledge, the number of hemizygotic deletions averages roughly six per tumor, with some tumors?breast and pancreatic, for instance?averaging up to ten. Each deletion involves 25 to 40 genes, many of them STOP genes, but also a few GO genes (growth enhancers and oncogenes) that enhance proliferation. That the STOP genes substantially outnumber their GO counterparts is important, Elledge explained, because it means cancer cells can tilt scales toward proliferation without also compromising it at the same time.

?The data reveal a lot of haploinsufficient players that have small effects individually, but large effects in combination,? Elledge said. ?Unfortunately, it?s not easy to see how to take advantage of that chemotherapeutically.?

What?s important about the results, he emphasized, is that they open up new views on how tumors evolve. Moreso, they underscore the importance of proliferation as a fundamental feature of tumor growth, he added.

The challenge now, Elledge said, will be to find out which of the genes in a recurring deletion are haploinsufficient. ?At the moment, we estimate roughly 25 percent,? he said. ?So these findings could also have important ramifications for other human diseases in addition to cancer.?

Reference: Harvard Medical School

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Learning Ping Pong On a Spending budget Via Table Tennis Video ...

Practically all sports have their instructional movies. Basketball videos can educate you the best way to shoot a ball right into a hoop though evading oncoming opponents; soccer video clips can instruct you how to kick a ball right into an aim though skirting fearlessly and readily previous coming defense, ala Diego Maradona; and desk tennis videos can display you ways to ship just a little hollow ball hurtling and spinning through the air, so that it can get into your opponent?s play but without your opponent hitting it. Tutorial videos will present you ways to rating and succeed, and can even educate you a thing or two of one?s activity of choice?s background, to ensure that you are able to appreciate the sport better.

Numerous sports activities tutorial videos, nonetheless, can be highly-priced. This has prompted a lot of business people, at the same time as skilled gamers, to launch their own websites and give free educational video clips. Desk tennis isn?t any exclusion: you?ll be able to obtain desk tennis video clip clips on line, and whether they?re absolutely free or paid-per-view, they are able to make it easier to comprehend table tennis and perform the game nicely.

Some desk tennis video clip clips will simply demonstrate you the history in the activity, in addition to its guidelines and regulations, and using the present leaders in the sport. Even though this might be dull to get a participant who?s not into lectures and classes, it can make it easier to realize why particular guidelines are produced in particular approaches. Video clip clips of table tennis guidelines can also make you visualize rule violations superior, in order that you can rating games properly in the future. Additionally, should you see the sport?s present finest gamers in motion, you can have some individuals to appear up to in an effort to improve your recreation.

Some desk tennis video clip clips will demonstrate you the physics behind the sport. They?ll explain how different taking part in surfaces can influence the trajectory of the ball, or even the ability of gamers to perform a match effectively. They?re going to explain how the two diverse paddle surfaces can ship the ball flying in different instructions, and with various spins. Observe this kind of video clip clips quite carefully, as they are going to show you all the points you?ll want to strategize effectively to get a wonderful activity of table tennis.

Other desk tennis video clip clips will display you the best way to play the game: you should know the distinctive methods of dealing with the table tennis paddle, and the way every single dealing with system impacts your perform; additionally you have to know how certain postures and movements on your component can result in harm if you?re not careful in the course of your desk tennis video game. Have a paddle available while you are viewing desk tennis video clips. As this is an tutorial video, you might want to watch it in your ft, and in player?s place, as although you had been prepared to perform an activity.

Still other desk tennis video clips will demonstrate desk tennis games in action. Observe how the game swiftly changes, and the way the pace is frenetic throughout. You need to maintain this amount of power in your desk tennis match, so watch how the gamers utilize their power in order that it stays up throughout their play. If you can, decelerate the video so you are able to see how particular successful pictures are produced. Using this method, you may completely appreciate the trouble in the match, and possibly be pressed to mastering even more about tips on how to play table tennis even improved.

Desk tennis video clip clips provide a less expensive alternative to purchasing entire videos. You could skip parts that you simply completely have an understanding of and appreciate, and you are able to view the parts that you simply like and have to have more than and more than again. There are lots of resources of table tennis video clips on the web: all you must do is search for them via your favorite online search engine, and look for web-sites that give credible table tennis video clip clips for free, or for the lowest value. With practice and observation, you?ll be able to flip your desk tennis video game about, due to desk tennis video clip clips.

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Amid eurozone turmoil, Germany borrows money for free

Germany sold $5.7 billion of debt today to yield 0 percent, a reflection of how much Europe's largest economy has diverged from its southern neighbors who are paying far more to borrow.

By Michael Steininger,?Correspondent / May 23, 2012

(L.-r.) Italy's Prime Minister Mario Monti, Germany's Chancellor Angela Merkel and France's President Francois Hollande attend an informal EU leaders summit in Brussels May 23. European leaders will try to breathe life into their stricken economies at a summit over dinner on Wednesday, but disagreement over the issue of mutual eurozone bonds and whether they can alleviate two years of debt turmoil will dominate the gathering.

Francois Lenoir/Reuters

Enlarge

Germany's central bank borrowed ?4.5 billion ($5.7 billion) today. The interest demanded by lenders in return? Nothing, a measure of the panic in the rest of the eurozone.

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?That?s a very good result for us,? said a spokesman of Germany?s Federal Finance Agency in Frankfurt, which manages the sales. ?It is an impressive illustration of investors? search for quality.?

But the first time in history the German central bank sold two-year notes to yield zero percent is evidence of how much trouble the rest of Europe is in. The free money for Germany amount to a loss for investors after inflation. Why are bankers willing to lose money on a loan to Germany? Because it isn't Greece. Or Italy. Or Spain.

Germany is not only one of the few growing European economies but its domestic finances are rock solid, unlike its eurozone peers. Spain and Italy are paying? more than six percent to borrow, because investors fear they'll default. European bankers, worried about ending up holding worthless paper, have few good options but the Bundesbank.?

Seven percent is perceived as the threshold beyond which borrowing becomes unsustainable ? Greece, Portugal and Ireland all asked the European Union and International Monetary Fund for financial aid after their borrowing costs breached that threshold.

The zero-interest sale reflects investors' interest in "a return of their money over a return on their money,"?Rabobank rate strategist Richard McGuire told Reuters.

High interest rates are exacerbating the economic problems in southern Europe. Greece, now in its fifth year of recession, seems more and more likely to leave the eurozone. Even after negotiating a far-reaching debt reduction with private investors earlier this year, the country won?t be able to service the remaining debt. Reuters quoted two Eurogroup officials today confirming that member states are being asked to prepare individual contingency plans for the eventuality of a Greek exit.?

While Germany made its record-breaking bond sale, EU leaders prepared for yet another crisis summit. Tonight they are convening for an informal meeting in Brussels to discuss measures to stimulate economic growth in the eurozone. The meeting is seen as the first battle between German Chancellor Angela Merkel, who strictly objects to growth programs financed through additional borrowing, and the new French president, Francois Hollande, unofficial spokesman for the growing group of leaders who advocate credit-based stimulus plans.

Before the meeting, Germany?s deputy finance minister, Thomas Steffen, rejected renewed calls for the introduction of eurobonds ? debt securities issued by the eurozone as a whole which in effect would mean that Greece could borrow at the same rate as Germany.

?We would sign up for 100 percent liability for new debt in the euro area,? Steffen said in Berlin today. ?We can?t do this, we?re not strong enough economically.?

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Saturday, May 26, 2012

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The 2009 Technology Innovation Awards | mainefarmsforthefuture ...

M edical detective work may have just gotten a lot easier.

Just how difficult it is gets highlighted every time an infectious disease sweeps the globe, as the new strain of swine flu did earlier this year. Current methods of testing for disease-causing microbes are pretty effective at discovering whether an infected fluid or tissue sample contains a known virus or bacteria. But trying to detect previously unknown organisms is a whole different story.

The Journal Report

See the complete
Technology
report.

To address this problem, David Ecker, co-founder of Ibis Biosciences Inc., and a team of researchers developed a sensor able to quickly detect and identify all the pathogens in a given sample.

The equipment promises not only to alert health officials to new disease strains, but also to guard against bioterrorism and enable hospitals to identify antibiotic-resistant bacteria.

Abbott Laboratories

and its Ibis Biosciences unit, which developed the Ibis T5000 sensor, took the Gold in this year?s Wall Street Journal Technology Innovation Awards.

The Silver award went to Touch Bionics Inc. for its i-Limb artificial hand, which features bendable fingers and a rotating thumb. The hand uses sophisticated motors and computer controls to grip objects and move in ways that traditional prosthetic hands can?t.

Vihaan Networks Ltd., an Indian telecommunications company known as VNL, won the Bronze award for a solar-powered base station to bring cellphone access to remote rural villages. The inexpensive base station can be quickly assembled and set up by unskilled villagers, and can run entirely on the built-in solar panels and batteries.

For the ninth annual Innovation Awards, a Journal editor reviewed nearly 500 entries, sending more than 180 to a team of judges from research institutions, venture-capital firms and other companies. Judges considered whether innovations were truly groundbreaking and new this year looked at whether their application would be particularly useful in a time of economic hardship.

ATECOVER

ATECOVER

Lloyd Miller

And the winners in each category are?

Computing Systems

Capturing real-life motion to use in computer animation can be complicated. Typically, actors are filmed wearing bodysuits covered with glowing dots or embedded with sensors that trace their movements, then high-powered computers use that data to help create characters that move realistically.

New York-based Organic Motion Inc. won in the computing-systems category for developing a motion-capture system that doesn?t require bodysuits or markers.

The core of the system is technology that uses sophisticated software to produce a digital clone of a person being filmed. Fourteen video cameras capture images simultaneously and send them to a standard computer with a high-end programmable graphics card, making the system far cheaper than the specialized equipment used in movie special-effects shops.

Organic Motion systems are being used in the creation of virtual environments for training coal-mine rescue personnel and for helping returning military veterans readjust to civilian life. Andrew Tschesnok, the company?s chief executive and founder, says future versions will work with next-generation game consoles for more-lifelike game experiences.

Consumer Electronics

Taiwan?s Industrial Technology Research Institute, or ITRI, won in the consumer-electronics category for its work developing a paper-thin, flexible speaker.

Researchers at ITRI, a nonprofit organization, devised a way to create arrays of tiny speakers that can be combined to produce high-fidelity speaker systems of almost any size.

Because the fleXpeaker is lightweight and consumes little power, it could be attractive for use in cellphones or in car sound systems. Other possible applications include giant banners that could be used to deliver public-service announcements in train stations or advertising messages in shopping malls.

ITRI is seeking to license the technology or create a spinoff company to commercialize the product.

Energy

SFC Smart Fuel Cell AG, based just outside Munich, won in this category for developing small, lightweight fuel cells that can be used by soldiers instead of much bulkier, heavier batteries to power communications and navigation devices and other battlefield equipment.


One advantage of the SFC fuel cells is that they produce power from methanol. Many fuel cells produce electricity from hydrogen. But hydrogen is highly explosive, so it needs to be stored in special heavy-metal cartridges. Cartridges for the SFC fuel cells are less expensive, lighter and less bulky.

Environment

Serious Materials Inc. of Sunnyvale, Calif., was recognized in this category for its EcoRock drywall substitute, which is made with recycled material and, the company says, requires 80% less energy to make and produces 80% less carbon dioxide than standard gypsum-based drywall. EcoRock, which is also termite- and mold-resistant, will be priced to compete with premium drywall products. Serious Materials has been selling limited test quantities of the product to a few contractors since early this year and plans to expand production and distribution over the next two years.

Though some judges wondered if a relatively high price would limit how widely the product is used, it is a ?novel solution to a basic problem that has enormous impact,? says Darlene Solomon, chief technology officer of Agilent Technologies

and an Innovation Awards judge.

Health-Care IT

DataDyne.org, a Washington-based nonprofit, and its co-founder, Joel Selanikio, won in this category for EpiSurveyor, free software for mobile devices designed to help health officials in developing countries collect health information.

INNOVPLEXID

INNOVPLEXID

Abbott Labrotories

The latest version of the T5000 biosensor from Ibis Biosciences

In developing countries, gathering and analyzing time-sensitive health-care information can be a challenge. Rural health clinics typically compile data only in paper records, making it difficult to spot and to respond quickly to emerging trends.

With EpiSurveyor, developed with support from the United Nations Foundation and the Vodafone Foundation, health officials can create health-survey forms that can be downloaded to commonly used mobile phones. Health workers carrying the phones can then collect information about immunization rates, vaccine supplies or possible disease outbreaks when they visit local clinics. The information can then be quickly analyzed to determine, say, whether medical supplies need to be restocked or to track the spread of a disease.

The software has been rolled out in more than 20 African countries.

Materials and Other Base Technologies

Light fixtures based on light-emitting diodes semiconductors that glow brightly when charged promise long-lasting, low-energy illumination. But there?s a problem: The light produced is harsh and bluish in color. Special filters can be added to produce warmer tones, but they can make the fixtures less efficient. Devising a way to make warmer-colored, high-efficiency LEDs is seen as essential to their widespread adoption.

QD Vision Inc. of Watertown, Mass., won in this category for inventing a way to dramatically improve the color quality of LED lights by using quantum dots tiny semiconducting nanocrystals. QD Vision quantum dots can also be used to make energy-efficient flat-panel and other displays that can deliver purer, more intense colors.

The company recently joined with a small LED light-fixture maker, Nexxus Lighting Inc.,

to make a screw-in LED bulb. The bulbs, which promise to be six times more efficient than incandescent bulbs, are expected on the market later this year.

Medical Devices

The i-Limb from U.K.-based Touch Bionics, the overall Silver winner, received top honors in this category.

Prosthetic hands typically have been limited to simple pincer-like grips that imitate the motions of a thumb and forefinger. While they can perform most essential hand functions, they lack the utility and appearance of a real hand.

The trick in developing the i-Limb was coming up with materials that could match the shape and weight of a human hand yet be powerful enough to handle all the tasks of muscle and bone. The hand uses motors that fit in the space of a knuckle to control the fingers; the motors are controlled by a computer chip.

With the hand, wearers can grip and turn a key, for instance, or hold a business card using a thumb and index finger. They can also close all the fingers and the thumb around an object, like a drink can or a shopping-bag handle. It?s also possible to point with the index finger, which is useful in operating a phone or a cash machine, among other things. The thumb can also be rested next to the rest of the hand, so that it doesn?t snag when putting on clothing.

Adding to its life-like appearance, the i-Limb comes covered with a flexible silicone skin. But wearers don?t have to go with the natural look. Stuart Mead, Touch Bionics? chief executive, says a lot of younger wearers prefer either a clear skin that shows off the device?s inner workings or a black metallic covering ?that looks a little like Darth Vader.?

innov_limb

innov_limb

Touch Bionics Inc.

The i-Limb artificial hand, from Touch Bionics

Medicine-Biotech

Abbott?s Ibis Biosciences unit, the overall Gold winner, was the top entry in this category. The technology takes a novel approach to detecting and identifying pathogens. When faced with unidentified organisms, clinical labs typically have to incubate infected fluid or tissue samples and test them for bacteria or viruses. Newer microarray technologies can run thousands of such tests simultaneously. But they are expensive and require lots of high-quality genetic material for their analyses, making them less than ideal for diagnostic purposes, says Mr. Ecker, a divisional vice president at Abbott. (Last year?s Silver award winner, the PhyloChip, is a microarray system for detecting bacteria in water and other environmental samples.)

Ibis uses a combination of technologies to identify organisms: mass spectrometry a way of identifying the molecules that make up a sample by measuring their mass and charge to determine the genetic markers of the organisms in a sample; a vast database of genetic signatures for different organisms; and a mathematical process to match the analysis with the signatures in the database. The test not only can reveal all the known organisms present in the sample, it also can also flag previously unknown organisms. Since the first system was completed in 2005, Ibis sensors have been deployed in 20 sites around the U.S., including the Centers for Disease Control. This spring, the device helped the Naval Health Research Center in San Diego to identify the first two cases of the H1N1 swine flu in the U.S. Abbott, a health-care company based in Abbott Park, Ill., acquired Ibis earlier this year.

Security Privacy

Ksplice Inc., based in Cambridge, Mass., won in this category for software that makes it possible to install security patches and other software updates without rebooting computer systems.

Celebrating the Winners

The winners of The Wall Street Journal?s 2009 Technology Innovation Awards will be honored Oct. 13 at a ceremony and dinner in Redwood City, Calif. Featuring a keynote address by Marc Benioff, chairman and chief executive of Salesforce.com Inc., the ceremony will be held in conjunction with the Dow Jones VentureWire Technology Showcase.

The VentureWire Technology Showcase will spotlight 75 of the industry?s most innovative companies, and will featurekeynote presentations by Bruce Aust, executive vice president of the corporate client group at Nasdaq OMX Group Inc.; Guido Jouret, chief technology officer of the emerging-technologies group at Cisco Systems Inc.; Mary McDowell, executive vice president and chief development officer, Nokia Corp., and Walter Mossberg, Wall Street Journal personal-technology columnist.

For information about the ceremony or conference, visit Showcase.DowJones.com or send an email to EventsRSVP@dowjones.com. For an application for the 2010 Innovation Awards, email Innovation@wsj.com. Applications will be available in December.

Software makers periodically send out updates, and before they can take effect the computer system needs to be shut down and restarted. So even critical security updates are often delayed until late at night or weekends when shutdowns are less disruptive. Ksplice was developed so that companies can perform updates without interrupting their operations. The software was first deployed commercially last year, and the company has about a dozen customers. Though it currently is available only for Linux-based systems, the techniques can be applied to other operating systems, says Jeff Arnold, the company?s president and co-founder.

Semiconductors

Qualcomm Inc.,

the San Diego-based wireless-technology company, won in this category for a mobile-device display it calls mirasol, a low-power, full-color alternative to traditional displays.

The mirasol display uses micro-electromechanical systems, or MEMS, and thin-film reflective material to produce color images that remain vivid even in direct sunlight. The displays are able to produce a full color spectrum, and images are refreshed quickly enough that full-motion video can be displayed as well as static images. By relying on ambient light, the displays require little power. The technology was originally developed by Iridigm Display Corp., which Qualcomm acquired in 2004 and renamed Qualcomm MEMS Technologies.

The first black-and-white displays using the technology became available in early 2008 and have been used in mobile navigating devices, Bluetooth headsets and MP3 players. The company introduced a color version in May, and has agreed to provide the displays for future cellphones from LG Electronics Inc.

Software

Cloud computing promises to replace the complex array of hardware and software that makes up a company?s information-technology infrastructure with simple IT services delivered over the Internet, much the way that utilities provide electricity. But not all businesses can take advantage of cloud computing?s benefits because of security concerns, or because they already have significant investments in their own data centers and other IT systems.

The latest version of VMware Inc.?s

virtualization software suite, called vSphere, is this year?s winner in the software category. It promises to make it easier to turn a company?s existing data centers into a private cloud an array of IT services delivered throughout a company over its own computer network that?s secure, reliable and easy to manage.

VMware has long been the market leader in virtualization software, which makes it possible to run different applications or operating systems on a single computer by dividing the computer into several ?virtual? machines, each running programs independent of the others.

INNOVNL

INNOVNL

Shashwat Nagpal

A solar-powered base station for a cellular network, from VNL

With vSphere, which VMware describes as a ?cloud operating system,? IT managers can quickly turn all the servers in a data center into a network of virtual machines. A simple dashboard makes it possible to see all the applications that are running on each virtual device.

Judges noted that there is a lot of interest in private clouds, and said that VMware has taken a big step in helping companies build them.

?It?s a very important trend, and these guys are clearly the leader,? says Asheem Chandna, a partner at the venture-capital firm Greylock Partners who was one of the Innovation Awards judges.

Wireless

The Bronze winner, VNL?s solar-powered base station for cellphone networks, led the wireless category.

Mobile-phone service can deliver huge benefits to developing countries. But getting cellphone coverage to remote, rural parts of India and other countries is hindered by high installation and operating costs, as well as the specialized knowledge needed to set up and run a cellular station. As a result, few operators have gone into these communities.

VNL is looking to overcome this obstacle with a low-power cellular base station that requires little capital expense and has almost no operating costs. The base stations can be powered by a small solar panel in daylight; batteries provide backup power for up to 72 hours.

Another challenge was making the device so simple that it can be installed at low cost by villagers.

The solution was inspired by the Scandinavian retailer Ikea: The entire base station comes delivered in six boxes, small enough to all fit in an ox cart. Simple illustrated instructions show how to put the pieces together using color-coded cables.

Even turning the station to the right microwave signal is easy it emits a continuous beeping sound when the signal is strongest.

The technology may not be much of a technical breakthrough, but ?it?s worthy because of what it might bring to developing countries,? says William Webb, head of research and development at Ofcom, the U.K. communications regulator, and one of the Innovation Awards judges.

?Jan Hromadko, a Dow Jones Newswires reporter in Frankfurt, contributed to this article.

?Mr. Totty is a news editor for The Journal Report in San Francisco. He can be reached at michael.totty@wsj.com.

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Backlash against African migrants in Israel

An African migrant drives his car with a shattered window after protesters saw him on their way back from a rally against the flow of African migrants into Israel, in Tel Aviv, Israel, Wednesday, May 23, 2012. Hundreds of people gathered in south Tel Aviv Wednesday to protest against the government's handling of the flow of African migrants into Israel. Some of the demonstrators shattered a windshield of a vehicle in which three African migrants were travelling. Police arrested two people suspected of attacking a foreign worker during the protest. (AP Photo/Ariel Schalit)

An African migrant drives his car with a shattered window after protesters saw him on their way back from a rally against the flow of African migrants into Israel, in Tel Aviv, Israel, Wednesday, May 23, 2012. Hundreds of people gathered in south Tel Aviv Wednesday to protest against the government's handling of the flow of African migrants into Israel. Some of the demonstrators shattered a windshield of a vehicle in which three African migrants were travelling. Police arrested two people suspected of attacking a foreign worker during the protest. (AP Photo/Ariel Schalit)

(AP) ? Recent rapes blamed on African migrants have ignited a political and emotional backlash against their ballooning numbers, with Israelis and their leaders stridently ? and in an alarming new development, violently ? calling for their expulsion.

Israel, bound by an international refugees treaty it ardently promoted, doesn't seem to have that option, and the gap between rhetoric and reality threatens to send simmering social antagonisms boiling over into open conflict.

It has raised questions, relevant all over the developed world, about how much is owed to the impoverished migrants who manage to sneak in.

Over the past seven years, as many as 60,000 African migrants, most from Sudan and Eritrea, have slipped across Israel's border with Egypt, exploiting the lack of a physical barrier and widespread lawlessness in the Sinai Peninsula that has been one result of the fall last year of longtime Egyptian ruler Hosni Mubarak.

Israel is erecting a barrier along the roughly 200 kilometers (125 miles) of border. While this work drags on, the migrants continue to arrive at a rate of about 1,000 a month, ragged and penniless, with some reporting being raped, tortured and extorted by the Bedouins who smuggle them through.

Some migrants are fleeing repressive regimes. Others are simply looking for a better life in a richer country. How many fit into each of those categories is a matter of deep disagreement between officials and migrant advocates.

Some Israelis worry that their national identity as a Jewish state is being threatened by unauthorized African migrants, who now make up less than 1 percent of Israel's population.

"It's the crumbling of the Zionist dream," Interior Minister Eli Yishai warned on Thursday.

Officials claim the overwhelming majority of the migrants are not bona fide refugees escaping persecution and war, but economic migrants looking for jobs. Israeli leaders use terms like "infiltrators," ''cancer" and "national scourge" to describe them, setting an inflammatory tone.

After the first rape was reported earlier this month, Yishai declared nearly all migrants to be criminals and said they should all be jailed pending deportation.

Days later, Prime Minister Benjamin Netanyahu warned, "60,000 infiltrators are liable to become 600,000, and lead to the eradication of Israel as a Jewish and democratic state."

The issue of how to deal with them has also caused introspection about whether Israel, after a century of conflict with Arabs, has become a racist society.

"What disturbs me most is the racist atmosphere," social commentator Tom Segev said. "For several years now, Israel society has been moving in that direction, with all the anti-Arab motions in the parliament. ... I think that this society is very sick now."

Others deny that the pushback is racist, finding it unreasonable that their country of about 8 million should be expected to throw open its doors to unlimited numbers of migrants.

Israel cannot simply kick out the Africans, as some politicians would seem to suggest. As an enthusiastic backer of a 1951 U.N. treaty drafted to address the plight of World War II refugees, it has pledged not to expel asylum-seekers to any country where they would be in danger.

"We're not going to pull back on our obligations under the refugee convention," said Daniel Solomon, legal adviser to Israel's population and immigration authority. "At the same time, other solutions will have to be looked for," like finding a third country to take them in.

Because most migrants come from Sudan, an enemy state, and Eritrea, a country with an abysmal human rights record, the line between refugee and economic migrants is blurred. So Israel has quietly allowed most migrants from those two countries to stay, without processing their asylum applications.

The U.S. State Department criticized this practice in a report on global human rights released Thursday, noting that of 4,603 new asylum applications in 2011, Israel rejected 3,692 and approved one. According to the report, asylum seekers without refugee status are not allowed to work and have no access to public health care, and that the government negatively terms the migrants "infiltrators".

Spokesmen for Israel's prime minister and Foreign Ministry had no comment on the report Friday.

Because of their precarious status, the migrants scrounge for whatever underpaid and insecure employment and volunteer health care they can find.

"Our objective is to have Israel host these people under proper conditions until the option arises for them to go home," said William Tall, the envoy of the U.N. refugee agency office in Israel.

The Africans began trickling into Israel after neighboring Egypt violently quashed a demonstration by a group of Sudanese refugees there in 2005, killing at least 20. The numbers surged as word spread of safety and jobs in Israel, a prosperous and liberal country reachable from Africa overland.

The swelling numbers have spawned slums. Fear and intolerance is mounting among locals, who accuse the migrants of stoking crime, including three recent rapes ? even though police records show crime among the migrants is lower than among Israelis.

Firebombs were thrown recently at two buildings where migrants live, and a protest against them Wednesday in a poor southern Tel Aviv neighborhood where many Africans live turned violent. The crowd shattered windows of shops and cars belonging to Africans, police said, and a witness reported that protesters spat on migrants and cursed them. No one was hurt.

Bashir Abekker, 32, came to Israel four years ago to escape the war in Sudan's Darfur region. He thought he'd find safety, "but recently, I'm not safe here. I am afraid for my safety," he said. "After what happened (Wednesday), I was afraid to go out on the street to buy food."

On Thursday, Netanyahu condemned the violence. "I want to make it very clear that there is no room for the kinds of expressions and actions we saw last night," he said. "I say this both to public officials and to the residents of south Tel Aviv, whose pain I understand."

The Hotline for Migrant Workers advocacy group said the refugees are endangered by the "incitement" of politicians.

On the other side of the divide, neighborhood activist Dror Kahalani said the government is neglecting his already poor community to provide services for migrants, whose rising numbers terrify residents.

"I don't let my daughters go out unless I go with them," Kahalani said.

Prominent author and social commentator A.B. Yehoshua came to the defense of the migrants' Israeli neighbors. "We have to distinguish between economic migrants whom we don't have to accept, and the bona fide refugees who are suffering and face death if returned," he said.

For some, the violence against the migrants and calls for their expulsion are difficult to accept given the legacy of the Holocaust, when 6 million Jews were killed by German Nazis and their collaborators. They find it abhorrent that the Jewish state would expel people to face persecution elsewhere.

Others counter that following the mass murder of its own people as the world looked on, Israel has no more of an obligation to help others than the rest of the world does.

Associated Press

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