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Washington, DC--(ENEWSPF)--March 30, 2012. ?A nearly 15-year fight in the nation?s capital to allow patients suffering from cancer, HIV/AIDS and other diseases to use marijuana with a doctor?s recommendation has reached a crescendo, with the city naming six locations that will be allowed to grow medical marijuana legally under local law (including a company partly owned by celebrity talk show host Montel Williams). The announcement, which is sure to irk the Obama administration and some in Congress, comes at a time when U.S. Attorney General Eric Holder and the Justice Department are waging an unprecedented war on medical marijuana patients and providers in numerous states.
?The mayor and council should be commended for moving forward with DC?s medical marijuana program, even though the Obama administration has declared open season on medical patients and providers,? said Bill Piper, director of national affairs for the Drug Policy Alliance. ?Medical marijuana will soon be growing just blocks from the White House and Congress ? opponents of a compassionate marijuana policy need to realize that they?re on the losing side of history.?
DC voters first approved medical marijuana in 1998 but Congress blocked implementation of the ballot measure by prohibiting the district from enacting the law. That prohibition was repealed by Congress in 2009 and in 2010 the DC Council unanimously approved medical marijuana legislation, joining 16 states that allow patients to use marijuana with a doctor?s recommendation. The DC law allows up to ten cultivation centers and eight medical marijuana dispensaries to operate in the district. The locations of the medical marijuana dispensaries will be announced later this year.
Medical marijuana advocates worry about how the Obama administration will react. As a candidate for president, Obama said both that he supported the right of doctors to recommend marijuana to their patients, and that he would stop the federal government from wasting law enforcement resources on raiding, arresting and prosecuting people for medical marijuana, especially if they are complying with their state law. He made due on this promise in his first year in the White House. The Department of Justice issued guidance to US Attorneys urging them not to waste resources prosecuting people for medical marijuana who are in compliance with their state?s law.
In the last year, however, the Obama administration has changed course. The DEA has increased its raids on medical marijuana dispensaries. US Attorneys have sent letters to landlords who rent office space to dispensaries threatening to arrest them and seize their buildings under asset forfeiture laws. The Treasury Department has threatened to prosecute banks that open checking or savings accounts for dispensaries. The IRS has denied dispensaries the ordinary business expense deductions allowed for all other forms of businesses. The ATF has said that any medical marijuana patient who possesses a firearm will get ten years in federal prison. US Attorneys have even sent letters to state legislators and governors, timed to influence state decision-making processes, declaring that they might arrest people in their state if they pass a medical marijuana law or amend or expand existing medical marijuana laws.
Patient advocates worry that patients will lack access to the medicine they need if the Obama administration raids DC?s medical marijuana dispensaries and cultivation centers. Unlike most medical marijuana states, DC law prohibits patients from cultivating their own marijuana. DC is also the only medical marijuana state to make it a crime for a patient to possess marijuana not bought from a dispensary. If the Justice Department shuts down DC?s medical marijuana dispensaries and cancer, HIV/AIDS and other patients are forced to buy marijuana off the streets, they will face arrest, prosecution and incarceration.
?Given the Obama administration?s ongoing war on medical marijuana dispensaries, it is irresponsible of the DC Council not to allow patients to grown their own ? and it?s outright cruel to subject them to jail time for obtaining their medicine from whatever source they can,? said Piper. ?The DC Council should pass emergency legislation providing for a back-up plan in case the federal government shuts down local dispensaries.?
Smartphone applications ensure an user to enjoy better connectivity and advanced computing abilities than a feature phone. The earlier smartphones appeared to sport a combination of personal digital assistants (PDAs) and regular camera phones. However, in making a mobile phone rich with different functionalities, the contribution of these smartphone apps can never be ignored. Therefore, if you today want to access to a variety of features and functionalities on the move, the smartphone apps are the only way out. And not only these apps can help you in developing the latest and gaming interfaces, in terms of running a business successfully too they can offer a great help. It is perhaps due to this reason that today the global business houses are also showing much interest in developing intuitive and interactive smartphone applications.
These apps promises them to offer a lot of flexibility and comfort in running their business in a more comfortable manner and even when they are miles away from it physically.
However, before you are asking any web and smartphone apps development company to work on your project, you need to be sure of their quality of service. It is better if you know someone who has worked previously with the same company. Then you can source reliable information about the company?s quality of service and turnaround time. In case if you do not anyone who have been served by the same company previously, worry no more. Every web and application development company these days maintain a client information. Therefore, you can ask the company to pass on some of their valued clients? contact information so that you can approach some of these business houses to know about the quality of service of the selected web and smartphone applications development company. Always remember that only if you can gain a first hand information about the serviceability of a company, you can put your trust on them. Only thereby you will be able to enjoy a perfect win-win situation.
Anyone who is currently looking to develop smart and interactive applications for his or her smartphone is sure to be benefitted a lot by following these above mentioned steps. Today, one such a web development company that have earned substantial fame in developing apps for cross vertical projects is NETiT Solutions Pvt Ltd. With their well talented in-house programmers, herein you are sure to find the best of solutions. A unique level of world class expertise and technical knowhow are what that define the smartphone application developers of NETiT in the most perfect manner. So, whenever you come herein to get your apps developed, you can remain quite assured of witnessing a holistic practice by remaining within a affordable limit. Also as this company is equally proficient in maintain strict deadlines, clients from all over the world seek to get their applications being developed with such a sense of commitment and professionalism.
So, do not waste your time anymore. If you have any application to develop for your smartphone, talk to the experts right now!
A good mobile packages review is usually the starting point in lessening corporate mobile communication costs, which all have become a big line item on a large number of company spending budgets. Looking at packages regularly leads to a typical primary cost savings that is at least 20 %. Regardless of what size the corporation is, it is a significant total amount. The price savings usually do not stop right there as the plan comparison is only the preliminary step of the expense management plan meant for cellular devices.
Wireless providers advertise enterprise options as being the top deals intended for companies. Although they can be, they aren?t always. Picking out a prepackaged option designed to match all business customers oftentimes leads to spending too much money. The thing that makes this a whole lot worse is that even though business pays excessively, not all individuals have the features they want. The one person benefitting from this situation will be the carrier, who is given money for under used products.
The provider would not point it out, therefore the enterprise customer must identify the issue then do something to deal with it. A technology firm that focuses on mobile communication managing can help by doing an examination of one?s cellular phone and data packages. The results is going to pinpoint which wireless carrier or package changes are required. The auditing firm will work right with all the carrier?s networks for the greatest offer for the corporate client. Companies should acquire the solutions they require at the lowest prices. Through commissioning this audit on a consistent basis, an organization optimizes their communication costs.
A package comparison can do more than merely establish the best cellular phone plans. Furthermore, it will bring billing issues to light promptly. Companies frequently believe carriers don?t make some mistakes and as a consequence, Information technology as well as book keeping employees will not review carrier statements. The fact is that invoicing mistakes tend to be commonplace. If uncovered and taken to the attention of the company as quickly as possible, they could be corrected on time to receive a adjustment on the statement.
Service providers oftentimes try to make enterprise clients come to feel beholden towards them relating to the services getting supplied. Businesses should really keep in mind that they are the clientele in this relationship. Service providers should really be making an effort to acquire their business, not the other way round. A normal option assessment will keep service providers on their toes so they really continually make their very best plans accessible to prevent losing corporate clients. Firms can feel at ease realizing that they have the most suitable package at the lowest expense.
Information technology employees frequently execute option review as well as comparing responsibilities independently. With only a single service provider and a few phones, this task is usually quick and simple. As more service providers are added in, the volume of handsets increases, and type of handsets enlarges to include a variety of mobile phones and pc tablets, the project becomes more time-consuming and complex.
An auditing agency eliminates the burden of package comparing from central IT staff. This doesn?t mean that IT individuals must remove their selves totally out of the course of action. They simply have got another team there to validate their review, come up with recommendations relating to package optimization and even cost benefits, and offer device supervision service if needed.
Without taking a cell phone plans comparison, your company could be wasting a lot of unnecessary funds. With budgets being so tight these days, it is vital to save every dime possible. To maximize your business cell phone management, visit Gill-Technologies.com for help. Visit out site today for more information and pricing.
Inexpensive nevertheless Efficient Modest Business Advertising and marketing Method
Article by Donovan McFarlane
Are you a beginner in the on the web marketplace and wished to promote your modest organization? There are really a lot of small business advertising method that you can put into action and focus on your industry employing them. But before you go about the approach, the a single factor that you require to think about is your price range. Are you all set to invest excellent-sized money to do all the modest enterprise advertising method? For beginners, this is truly scary, particularly to people who are not experienced about the internet marketing and advertising ?technologies?. But will not get disappointed due to the fact with a little help from the specialists, which they get in touch with on their own internet marketing gurus, you can fuel your modest enterprise marketing and advertising approach and get the outcomes you require for your little business on the internet.Cost-effective little business marketing and advertising strategy that create benefits!Even so, the issue with selecting net marketing and advertising specialists is that, they can cost you a great deal. If you don?t have a spending budget to pay for it, may possibly as nicely settle for modest organization advertising approach that are inexpensive and even will come totally free. The only thing that you need to have below is expertise and total understanding of how every single technique operates. Will not stress due to the fact the small company marketing and advertising strategy that will be talked about here are basic and straightforward to pull off. * Pay out for every click on advertising and marketing ? This is one of the best modest business marketing strategy that you can apply. Google Adwords and Yahoo Advertising are the two most well-liked medium that supply pay out per click advertising and marketing campaigns. The good factor about it is that, you can control how much income you want to commit on specific key phrases. Also, you handle the money you want to devote on a regular monthly basis. The results of this little company marketing method is guaranteed simply because you are finding the focused traffic that you anticipate.
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* Ezine advertising ? This is a potent small company advertising and marketing strategy. The fact that there are several electronic mail newsletters today and have been about for numerous a long time and have tons of loyal viewers, you can use this to your edge. You distribute the term out through this small business marketing technique. This presents you all the opportunity to market your small organization to folks who are really reading your write-up, your categorised ad, or your solo ad. Tiny company marketing and advertising approach for Modest company proprietorsWith these three surefire little business advertising approach, expect to get the targeted traffic that you are expecting and see your revenue soar. But if you want know the key to making money out of your tiny enterprise, go to http://donovanmc.im-for.com. You will find out here established and time-tested tiny company marketing and advertising strategy that you have by no means known. This web site will show you how this key functions in ANY economic climate..no matter your opposition, area, or whether or not or not you?ve Ever marketed on the world wide web prior to! Get also totally free little business marketing approach that will support your organization soar.
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It's hard to think of two more contrasting crooners than the pair who took to the American Idol stage last night.
We had Nicki Minaj, who gyrated about and delivered an energetic performance of "Starships," scantily-clad outfit and all.
And then we had the season 10 champion Scotty McCreery, a laid back country boy who lets his deep, mature voice do all the work, in this case standing behind a mic and belting out a version of his new single, "Water Tower Town."
McCreery was also presented, as seen here, with a framed, enlarged version of his platinum debut album, "Clear as Day."
Which season 11 contestant might duplicate this success? Our money still must be on Phillip Phillips.
Too many people approach their fitness goals hesitantly. In many cases, they do not how to start, or simply lack the motivation to start. Motivating yourself can be as easy as making your workouts fun. The following tips may help you begin.
Workouts are not just about losing weight, they are about having fun. Try adding music to your workout to liven things up and make it that much more enjoyable. Your favorite tunes can be powerful motivational assistants that help you power through your exercise. Music will really help get you moving and improve your workouts. When you incorporate music into your workout routine, you will put yourself in the right frame of mind to enjoy your workout.
If you do not find ways to make exercising fun, it will be a lot harder to stick to your workout goals. Group activities can help make your workout less isolated and more fun. Recruit a buddy or several to accompany you on lunchtime strolls or trips to the workout facility. Making your workout more social can help you reconnect with friends and make your workout more fun than when you go at it alone. Working out with a pal can add elements of fun to an exercise plan, helping you to forget you are working out at all.
Workout video games can be a great weight loss tool. Exercising with a video game feels more like playing and having a good time than working out. If you are doing exercises that are enjoyable and fun, you will reduce the risk of getting tired and calling it quits.
Go shopping for exercise clothes to get your mind in the right place to exercise. Purchase exercise clothing that will help you feel good about your appearance. There are many styles available. Some workout gear can be both flattering to your figure and a lot of fun. Make it your chance to be creative! Don?t be afraid to be adventurous! You should choose exercise outfits that you like to wear so that you will feel good about going to the gym or working out.
Try to avoid doing the same exercises each day because, at some point, you just won?t feel like doing them anymore. Your exercise routine can come to a grinding halt if you allow yourself to get bored. Mix up your workout regimens in order to maximize your motivation and keep workouts fun and interesting. This is a vital point, because prolonged breaks from working out tend to make restarting far more difficult.
As we have just stated, tennis apparel is something that cannot be dismissed ? or at least should never be ignored. At times there is simply way too much to even try to cover in one go, and that is important for you to realize and take home. But I wanted to pause for a moment so you can reflect on the value of what you have just read. In light of all that is offered, and there is a lot, then this is a great time to be reading this. The last outstanding areas for discussion may be even more important.You should always give yourself a reward if you have done a good job. A reward provides the motivation you will need to complete the next step of your journey. You can treat yourself when you reach a milestone in fitness. However, do not go overboard with the rewards. Fitness is a reward in itself.
Many believe exercise is little more than an irritating task, however, it can be much more enjoyable than that. A variety of methods can be applied to make exercising more fun. This article contains the advice you need to develop a fun exercise routine.
Looking for a good spine center? Want to get rid of your back or spine problems? A spine center NJ can only treat your problems quickly and effectively. More and more Americans are suffering from back and spine problems which is definitely a matter of concern for the world, it actually happens for different reasons. Addressing the back and spine problem is only possible with the help of the spine center; make sure to choose the center which has experienced professionals who knows the right pain to treat all the different kinds of back pain. Back is one of the most important parts of the body, it supports the body.
Most of the spine centers usually directed by orthopedic surgeons with knowledge of the musculoskeletal system and also certified by the American Academy of Orthopedic surgeons. Orthopedic surgeon is provided training on spine surgery from the medical school which helps them to be learning about the spine surgery properly. Back pain is somewhere associated with pain management, it is very important to get the right treatment as soon as possible. Don?t be late! Stop thinking about your hard earned money. Health is important than any other thing in the world and deserved to be treated in a royal manner. If you are someone who doesn?t like going to hospitals, you should look for back pain center where you would be treated by a trained nurse.
Don?t ignore your back pain problem! Most of the people usually avoid treating back pain at the right time which creates more problems for them. More and more spine centers are opening up nowadays due to the increase in the spine related complications among people. Spine centers have qualified staff and services who provide treatment to all the patients suffering from back or knee pain problems. Spine centers does a complete analysis on the patient before starting the treatment procedure, it takes care of the patients individually on a cheap and affordable rate. Get specialized treatment at the spine centers and get your normal life back. Highly specialized services of the spine treatment centers help the patients to recover quickly.
Learn the right posture from the spine center NJ while you are walking or hooked on to the computer, you may also go for the non surgical treatments which also help to treat the back pain problem in a healthy way. Make sure to choose a good back pain center which experienced and qualified staff, it is the staff members who actually determines the service to be given to the patients. Spine centers appoint special staffs who have experience of treating the back pain problem in a proper way. Keep all these important information in mind while you are choosing the center for your pain problem.
Spend some time online to look for the different pain treatment services provided by the back pain centers, you should also check the online review of the pain centers to make the right choice. Treat your back pain at the best back pain center! Good luck!
Residents disagree over plans to convert a 500-year-old palazzo into a department store in Venice, Italy.
? A local, slice-of-life story from a Monitor correspondent.
Skip to next paragraph
Immortalized by Venetian painter Cana?letto, it forms the graceful backdrop to a million tourist snaps of Venice?s famous Rialto Bridge. But a plan to convert a 500-year-old palazzo into a department store has met with hostility here.
The Renaissance building, known as the Fondaco dei Tedeschi, overlooks the Grand Canal and was built in the early 16th century as the headquarters for German merchants. In the 20th century it became Venice?s main post office, but has stood empty and unused for several years.
Now there are plans to refurbish the building and slice off part of its roof to form a terrace with a panoramic view.
Italia Nostra (Our Italy), a heritage group, says the ?very serious alterations? will gravely compromise the architectural integrity and historical identity of the building. Nonsense, says the mayor of Venice, who is backing the plan. The project is due to begin by December 2012.
Get daily or weekly updates from?CSMonitor.com?delivered to your inbox.?Sign up today.
Compacting soil means the flood-prone city is sinking
Web edition : 4:13 pm
Venice is still sinking and will probably continue to do so for a long time, a new study suggests. That?s bad news for the local government, which had already put a stop to groundwater pumping in an effort to curb the city?s subsidence.
?It was thought that the sinking had pretty much been stabilized, but now we know it will continue into the future indefinitely,? says Yehuda Bock, a geodesist at the Scripps Institution of Oceanography in La Jolla, Calif.
Today?s sinking has little to do with human activities, Bock and colleagues report online March 28 in Geochemistry, Geophysics, Geosystems. Soil is compacting beneath Venice, bringing the city down with it. And Venice rides atop a slab of Earth?s crust that is slowly diving beneath the Apennine Mountains, giving the city a tilt noticed for the first time in the new study.
Data collected by GPS devices and satellite radar systems showed the city dropping an average of 1 to 2 millimeters per year between 2000 and 2010.
That?s significantly slower than it sank decades ago, says Bock, and slower than other cities such as New Orleans are sinking today. So some researchers don?t think this natural subsidence is worth worrying about.
?We think this is a very small number,? says Tazio Strozzi, a physicist with the GAMMA remote-sensing consulting company in G?mligen, Switzerland. Previous satellite measurements have detected a similar amount of subsidence, he says.
But Bock worries that even a millimeter or two a year could, over time, compound the risks of changing sea levels. During the 20th century, sea levels rose 13 centimeters at Venice, helping to make floods seven times more common.?
?They built barriers to raise during high tide,? says Bock. ?They?ll probably have to use them more often than they had anticipated.?
Physicians will respond on camera to questions during live streamed colonoscopy on March 28
SEATTLE, March 27, 2012 /PRNewswire-USNewswire/ -- Colorectal cancer doesn't broadcast its presence until it's too late. Swedish Health Services hopes to change that by getting the word out about safe and effective prevention options.
On Wednesday, March 28, 2012 from 9 a.m. to 12 p.m. (PDT), Swedish physicians and staff will host its first-ever online chat and video stream of a colonoscopy procedure. The stream will be made available online at www.swedish.org/colonlive.
In the United States today, colorectal cancer is the second leading cause of cancer-related deaths for both men and women. It is estimated that 51,000 people will die of the disease this year and 143,000 new cases will be diagnosed.
The American Cancer Society recommends that, upon turning age 50, everyone should get a colonoscopy to prevent colon and rectal cancers. The test is designed to find both early cancer and polyps (growths in your large intestine).
"Right now, only about 60 percent of patients get screened, even though the effectiveness in reducing deaths has been proven," said Dr. Raman Menon, a colon and rectal surgeon at Swedish. "Regular testing is a powerful weapon for preventing the onset of the disease. Removing polyps in the colon keeps the cancer from ever evolving into anything dangerous. The disease is easily treatable if found at an early stage."
"Education is our best, most cost-effective weapon against colorectal cancer," said Dr. Nicholas Procaccini, a gastroenterologist at Swedish. "Screening helps people stay well and it saves lives."
In nine of 10 patients who found their cancers early, their chance for survival in five years is high. Very often these people live a normal life span. If people neglect screening, the cancer can grow and spread without being noticed.
A colonoscopy takes about 30 minutes and is not painful. It is an internal examination of the colon, or large intestine, and rectum. It is done using an instrument called a colonoscope, which has a very small camera attached to a flexible tube that the examiner uses to scope the area. The procedure reviews the entire length of a colon.
As part of Colon Cancer Awareness Month, Drs. Menon and Procaccini will host an online chat and live stream featuring two colonoscopy procedures, one of a male and the other of a female patient. The live stream will be focused around the importance of undergoing routine colonoscopies after age 50 with a focus on advances in colonoscopy procedures.
During the live stream the public will have the chance to communicate with the physicians who performed the procedures and ask questions. The physicians will respond live on camera throughout the program. The dialogue will be focused around the importance of early detection in preventing and treating colon and rectal health issues. Anyone interested may also join the conversation via Twitter by using the hashtag #ColonLive.
Swedish is committed to identifying new ways of communicating to the community to better inform the public and provide important information about relevant health issues. Recently, Dr. Rod Kratz, a colon and rectal surgeon at Swedish, shared his experiences preparing for his first colonoscopy on YouTube. Dr. Kratz underwent his first at age 40 due to potential family history of colon and rectal health issues. His video can be found online here: http://www.youtube.com/watch?v=BVocXp-CYHU.
For more information, or to schedule your own colonoscopy, visit: http://www.swedish.org/colorectal ?or call 206-386-6600.
About Swedish
Swedish has grown over the last 102 years to become the largest non-profit health provider in the Greater Seattle area with 11,000 employees, more than 2,800 physicians and 1,700 volunteers. It is comprised of five hospital campuses (First Hill, Cherry Hill, Ballard, Edmonds and Issaquah); ambulatory care centers in Redmond and Mill Creek; and Swedish Medical Group ? a network of more than 100 primary-care and specialty clinics located throughout the Greater Puget Sound area. In addition to general medical and surgical care including robotic-assisted surgery, Swedish is known as a regional referral center, providing specialized treatment in areas such as cardiovascular care, cancer care, neuroscience, orthopedics, high-risk obstetrics, pediatric specialties, organ transplantation and clinical research. For more information, visit www.swedish.org, www.swedishcares.org, www.facebook.com/swedishmedicalcenter, or www.twitter.com/swedish.?
Swedish is affiliated with Providence Health & Services, which is a Catholic, not-for-profit organization founded by the Sisters of Providence in 1856 with 27 hospitals, 214 physician clinics and almost 53,000 employees across five states. Based in Renton, Wash., Providence Health & Services provides strategic and management services to integrated health-care systems in Alaska, California, Montana, Oregon and Washington state. For more information, visit www.providence.org.
Listen, I understand the pain that comes with not being able to afford nice things. I really do. But for the love of everything mighty, do not waste your money, or stand by as your loved ones waste their money, on cheap Android phones. Thanks to generous subsidies in the U.S., often only a few dollars separates a cheap Android phone from a top-tier model. With the exception of handsets like the Galaxy Note tabletphone, Droid Razr MAXX and Galaxy Nexus, all of which cost $299, there are a lot of quality Android phones to be had for just $199. Why get something like this lump, the $80 (after rebate) LG Lucid, and live with a bargain phone that will likely be shortly abandoned and destined to live without proper updates. You're setting yourself up for a bucket of fail.
?The Business of the Twenty First Century a Recipe For Success The Business of the Twenty First Century is a new book by Robert Kiyosaki. Kiyosaki is a well known trainer in business and personal finance. He is a strong advocate of creating your own wealth and building financial independence. To date his biggest success is Rich Dad, Poor Dad. It was in Rich Dad Poor Dad that Kiyosaki first talked about multi level marketing and how it could be one of the best ways to create you own wealth. In The Business of the Twenty First Century Kiyosaki further...
?The Slight Edge Audio Book Review Many times, people find themselves envying the success of a neighbor or a colleague at work. They wonder why they have not been able to achieve similar success. Some blame their lack of skills and others poor spending habits or behavior. To attract success, such people resolve to make fundamental changes to their lives. However, the changes they wish to make prove too difficult to sustain and in a month or two, eventually finally give up. The slight edge audio book teaches that small...
?Is Network Marketing the Perfect Business Network marketing is considered the perfect business because of all the ways it offers an income opportunity. It also allows you to control your own business right from the comfort of your own home, and doesn't cost an arm and a leg just to get set up. In fact, this is one of the easiest businesses to get started! With enough know how and commitment you can be up and running within a week. Network marketing gives you the opportunity to connect with others that might be interested in the same...
?The Making of a Legend J Earl Shoaff Author of How to Become a Millionaire J. Earl Shoaff is truly has an inspirational story of rags-to-riches. Nicknamed The Millionaire Maker, J. Earl Shoaff created an empire called the Nutri-Bio Corporation and became a millionaire in only four short years. Born March 21, 1916, J. Earl Shoaff came from a poor farming family. During the Great Depression while he was in the ninth grade, he decided to drop out of school so he could work and contribute financial support to his family. Shoaff was born with a heart condition and when he...
?The Power of Visualization by Dr Lee Pulos The power of visualization cannot be too strongly emphasized. The ability to relax your body into a meditative state and to get your mind where you want it to be has been a proven technique to reach the road to success. Learning visualization techniques used to require classroom time or time with a professional counselor. Testimonials from people trained in the power of visualization come from all areas of society. Often their paths to success were paved with the techniques associated with...
?The Slight Edge to Positive Change The Slight Edge At the beginning of every year, we always make resolutions about what we want to achieve in order to better our lives. In many end-of-year parties, it?s common to hear people pronounce things like; ?I am going to quit smoking this year? or ?By the end of the year, I am going to be a fully qualified CPA.? However, as the year ends, we suddenly realize what a failure we have become. Many of our goals are ambiguous and lofty. They are not specific and lack application mechanisms....
?The Fear Factory Go For No Training by Richard Fenton and Andrea Waltz Typically, the first thing we think of when we hear No is something negative. The Fear Factory Go For No Training program will help you turn that around by changing the way you think after hearing the word No. You will then be able to use that word No to help make you push, strive, and succeed at more than you ever thought you would. Don't worry about how your thoughts are to automatically make No a negative thing. That's actually what has been programmed into our brains since we were little....
?The Business School For People Who Like Helping People The network marketing industry has been referred to as The Business School for People Who like Helping People. This is a concept that deals with the idea that if you enjoy helping others succeed, you will be able to be successful yourself. Here are a few things to consider about the concept of network marketing and why it is such a valuable business model. Robert T. Kiyosaki wrote a book called The Business School for People Who like Helping People. This is a book that outlines the power of...
?New Rules to Get Rich in the New Economy There is little doubt that the world has seen tremendous change over the past century with the rate of change accelerating over the last few decades. This change has affected all aspects of life from the home to the office. The result is that processes that were part and parcel of life in yesteryears have either changed so much that they are unrecognizable or have moved on to complete redundancy. But with the changing technology that many are now so used to, not as many have recognized that a...
?The Four Hour Work Week by Tim Ferriss Tim Ferriss has truly come up with an innovative concept. He has devised something known as The Four Hour Work Week and it is considered a revolution concept. In particular, it deals with the notion of lifestyle design. Or, more accurately, it refers to the concept of effectively redesigning one's lifestyle to make it more likely to deliver on expectations. Why live a lifestyle that does not effectively allow you to attain your maximum potential? Tim Ferriss has opened the door to get the most...
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This is Pope Benedict XVI's first trip to the Latin American country; his predecessor, Pope John Paul II, made five trips over the course of his papacy.
By Adrian Gomez Licon and Michael Weissenstein,?The Associated Press / March 24, 2012
It had become tradition in Mexico. Before daybreak, youths would creep as close as security permitted and serenade their beloved Pope John Paul II with a song of greeting and celebration.
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Now a new, less familiar pope had come, seeking to strengthen his own ties with the largest Spanish-speaking Catholic nation.
So well before dawn Saturday, two dozen youths from a Guadalajara church group gathered near the school where the Pope Benedict XVI was staying. "We sang with all our heart and all our force," said Maria Fernanda de Luna, a member of the group. "It gave us goosebumps to sing 'Las Mananitas' for him."
RELATED:?Catholicism in Latin America: 5 key facts
Songs, joyful throngs, church bells and confetti welcomed Benedict as he began his first trip to Mexico, a celebration that seemed to erupt spontaneously out of what had been a thin, sun-dazed crowd.
As Pope Benedict XVI's plane appeared in the shimmering heat of Friday afternoon, people poured from their homes. They packed sidewalks five and six deep, screaming ecstatically as the pope passed, waving slowly. Some burst into tears.
Many had said moments earlier that they could never love a pope as strongly as Benedict's predecessor, John Paul II. But the presence of a pope on Mexican soil touched a chord of overwhelming respect and adoration for the papacy itself, the personification for many of the Catholic Church, and God. Thousands found themselves taken aback by their own emotions.
As a girl, Celia del Rosario Escobar, 42, saw John Paul II on one of his five trips to Mexico, which brought him near-universal adoration.
"I was 12 and it's an experience that still makes a deep impression on me," she said. "I thought this would be different, but, no, the experience is the same."
"I can't speak," she murmured, pressing her hands to her chest and starting to cry.
Belief in the goodness and power of the pope runs deep in Guanajuato, the most observantly Catholic state in Mexico, a place of deep social conservatism and the wellspring of an armed uprising against harsh anti-clerical laws in the 1920s. Some in the crowd came for literal healing, a blessing from the pope's passage that would cure illness, or bring them more work. Others sought inspiration, rejuvenation of their faith, energy to be a better parent.
Popes "have a personality, a positive energy. The simple fact of seeing him is a great satisfaction," said Jose Luis Perez Daza, a 47-year-old lawyer from Mexico City who was among thousands pouring off of buses Saturday and trudging three miles (five kilometers) to a sprawling campground in the city of Silao to await Sunday's papal Mass.
An international team of scientists, including some from Majorca and the Canary Islands, have described a new type of fossil scops owl, the first extinct bird on the archipelago of Madeira (Portugal). Otus mauli, which was also the first nocturnal bird of prey described in the area, lived on land and became extinct as a result of humans arriving on the island.
Twenty years ago, the German researcher Harald Pieper discovered fossil remains of a small nocturnal bird of prey in Madeira, which, until now, had not been studied in depth. The international team of palaeontologists has shown that the remains belong to a previously unknown extinct species of scops owl, which they have called Otus mauli.
"It has long legs and wings slightly shorter than the continental European scops owl from which it derives" Josep Antoni Alcover, one of the authors of the study and researcher at the Mediterranean Institute for Advanced Studies (IMEDEA), a mixed centre of the university of the Balearic Islands and the Spanish National Research Council (CSIC).
The result of the analysis of the proportions of the remains found, which has been published in the journal Zootaxa, reveals that Otus mauli could be a land inhabiting species that ate invertebrates and "occasionally lizards or birds".
"It is likely that their extinction is linked to the arrival of humans and the fauna they brought with them", Alcover explains. He also points out that their disappearance formed part of a pattern of extinction of the island's species, which occurred in virtually all the islands of the world.
According to researchers, amongst the causes of extinction of this scops owl, the destruction of its habitat is highlighted, as Madeira had a lot of serious fires during the seven years that followed the Portuguese arrival. Furthermore, humans brought new birds with diseases that were unfamiliar to the native species, as well as rats and mice that could prey on eggs of animals that had nests close to the ground.
Exclusive to Madeira?
The same or a similar species has been investigated in Porto Santo, another island of the archipelago of Madeira. "This is extremely interesting" the researcher says, "but difficult to assess because the materials found are limited and fragmented".
"If the scops owls of Madeira and Porto Santo were different species, it would mean that the Otus' flying ability is much more limited than continental scops owls. The distance between the two islands would be enough to isolate them" Alcover points out.
The homogeneity of the scops owls' measurements on the two islands, as well as the differences compared to European scops owls suggests that they were genetically isolated from the European populations. The distance between the continent and the island was enough to explain the difference in the species.
On this island they expect to discover new species of birds in the near future "which will report a world that disappeared just a few hundred years ago". "The same thing will happen in the Azores islands where there is already evidence that a scops owl different to the ones in Madeira and Europe that is also extinct" the scientist says.
###
FECYT - Spanish Foundation for Science and Technology: http://www.fecyt.es/fecyt/home.do
Thanks to FECYT - Spanish Foundation for Science and Technology for this article.
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Main Category: Breast Cancer Also Included In: Anxiety / Stress;??Psychology / Psychiatry Article Date: 23 Mar 2012 - 1:00 PDT
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A team of researchers led by Michael H. Antoni, director of the Center for Psycho-Oncology Research at the University of Miami (UM) has shown that a stress management program tailored to women with breast cancer can alter tumor-promoting processes at the molecular level. The new study recently published in the journal Biological Psychiatry is one of the first to link psychological intervention with genetic expression in cancer patients.
According to the study, the group-based Cognitive-Behavioral Stress Management (CBSM) intervention designed by the researchers affects which genes in the cells of the immune system are turned on and off, in ways that may facilitate better recovery during treatment for breast cancer, explains Antoni, professor of Psychology in the College of Arts and Sciences, and professor of Psychiatry and Behavioral Sciences and program leader of Biobehavioral Oncology at the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.
"For the women in the CBSM groups, there was better psychological adaptation to the whole process of going through treatment for breast cancer and there were physiological changes that indicated that the women were recovering better," Antoni says. "The results suggest that the stress management intervention mitigates the influence of the stress of cancer treatment and promotes recovery over the first year."
Previous research has shown that during times of adversity, our nervous and endocrine systems send signals to the immune system, which defends us from disease. In response, our body activates specific genes inside immune cells called white blood cells or leukocytes, Antoni explains.
"For the women that participated in the intervention groups, the genes that signal the production of molecules associated with a healthy immune response, such as type I interferon were up-regulated - meaning they were producing more of these substances, compared to levels seen in the control group," Antoni says. "At the same time, the genes responsible for the production of substances involved in cancer progression, such as pro-inflammatory cytokines, chemokines and matrix metalloproteinases were down-regulated."
CBSM is a 10-week group-based program developed at UM that combines relaxation, imagery and deep breathing, along with cognitive behavior therapy, which is designed to help patients reduce bodily tension, change the way they deal with intrusive stressful thoughts, decrease negative moods, and improve their interpersonal communication skills. In the study, 79 women undergoing primary treatment for stage 0-III breast cancer were randomized into a 10 week CBSM program or a psychoeducational control group in the weeks following surgery. Six month and 12-month follow up assessments were conducted.
"You essentially have this timeframe in a woman's life where she is getting diagnosed with breast cancer, followed by surgery, then chemotherapy or radiation, and it's very stressful," Antoni says. "This can be an emotionally and physically exhausting period offering little opportunity for recovery. If stress affects the immune system in a negative way, then their recovery could be slowed down and those patients taking longer to recover may be at risk for poorer health outcomes. Conversely, if stress management intervention can reduce the impact of stress on the immune system then recovery may be hastened."
The research team plans to follow the women in this cohort to see if CBSM intervention and its effects on leukocyte gene expression are predictive of reoccurrence and/or long term health outcomes.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source. Visit our breast cancer section for the latest news on this subject. The study titled "Cognitive-Behavioral Stress Management Reverses Anxiety-Related Leukocyte Transcriptional Dynamics" was funded by the National Cancer Institute and The Pap Corps, Champions for Cancer Research. Co-authors are Susan K. Lutgendorf, professor of Psychology, University of Iowa and Holden Comprehensive Cancer Center; Bonnie Blomberg professor of Microbiology and Immunology, and member of the Tumor Immunology and Biobehavioral Oncology programs at Sylvester; Charles S. Carver, professor and director of the adult program in the Department of Psychology and member of the Biobehavioral Oncology program at Sylvester; Suzanne Lechner, research assistant professor of Psychiatry and Behavioral Sciences and member of the Biobehavioral Oncology program at Sylvester; Alain Diaz, research associate, Department of Microbiology and Immunology, Miller School of Medicine; Jamie Stagl, graduate student in the Clinical Health Psychology program at UM; Jesusa M.G. Arevalo, research associate, UCLA School of Medicine, and Steven W. Cole, professor of Medicine, UCLA Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and Norman Cousins Center for Psychoneuroimmunology. University of Miami Please use one of the following formats to cite this article in your essay, paper or report:
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Salk scientists open new window into how cancers override cellular growth controlsPublic release date: 21-Mar-2012 [ | E-mail | Share ]
Contact: Andy Hoang ahoang@salk.edu 619-861-5811 Salk Institute
Worm model of back-up telomere repair strategy could speed identification of anti-cancer drugs
LA JOLLA, CA----Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome.
Loss of telomeres forces cells out of the dividing game and into a growth arrest state called "senescence," but cancer cells evade this by employing an enzyme called telomerase to extend eroded telomeres.
If telomerase fails to activate, the tumor cells of about 10 percent of all human cancers have a back-up strategy to build serviceable telomeres and keep dividing. How that pathway, called ALT for alternative lengthening of telomeres, works is unclear, because researchers have had limited options to study it experimentally.
Now scientists at the at Salk Institute for Biological Studies have created roundworms that eke out an existence, and even manage to reproduce, relying solely on ALT to maintain telomeres. That study, published March 16 in EMBO Journal, provides a valuable tool to tinker with the ALT pathway and learn how to block it, with a goal of forcing tumor cells to senesce.
"These worms are the first multicellular organisms we can study in the laboratory that maintain their telomeres through the ALT pathway and not through telomerase," says Jan Karlseder, a professor in Salk's Molecular and Cell Biology Laboratory and the study's senior author. "Up to now we could only study ALT in cell lines derived from tumor cells. Now we can screen for compounds and genes that suppress or regulate ALT in a whole organism, which in worms is fairly easy to do."
The components of telomere-building pathways are prime targets for cancer researchers. "There is a huge interest in drugs that block telomerase, since 90 percent of cancers use it for telomere maintenance," says Daniel Lackner, a postdoctoral fellow in the Karlseder lab and one of the study's first authors. "But these drugs won't work for the 10 percent of cancers that use the ALT pathway. In fact, some evidence suggests that drugs targeting telomerase might actually increase ALT, making the need for ALT inhibitors more pressing."
The new study stems from a 2008 study from the Karlseder lab that was published in Cell. In that paper, they mutated a gene encoding a telomere-binding protein in roundworms. The resulting mutants displayed functional, but slightly scruffier-looking telomeres than those built by telomerase. That was a strong hint that when forced, worm cells, like human cells, can turn on the ALT pathway.
For the new study, the team pushed the mutant worms' survival capacity to the limit. This time they knocked out a second gene, telomerase itself, and found that these double mutants could reproduce continuously without undergoing senescence. Over the past 3 years a strain of double mutant worms has propagated for over 180 generations.
The group then used biochemistry to confirm that the worms depend totally on ALT for telomere maintenance. The telomeres of double mutants were more sloppily constructed than superior, telomerase-made caps and were similar in length and overall structure to chromosome caps displayed by human cancer cells that employ ALT.
The double mutant worms also contained wisps of telomeric DNA, called c-circles, that are unique by-products of ALT, further evidence that they were persisting via ALT.
Intriguingly, other investigators have reported that c-circles are present in the blood of human bone cancer patients and could potentially serve as a diagnostic for cancers that depend on the ALT rather than the telomerase pathway.
Although the worms are living long, species-wise, they are not quite prospering---- which is exactly what one would expect. The study reports that the double mutants have fewer offspring than normal worms, which is how roundworms exhibit "stress." And many have fused chromosomes, a likely outcome of having barely serviceable telomeres. But what counts is that the animals are viable, rely on ALT only, and their genome reflects aberrations seen in human tumor cells. In short, they are ready for analysis.
Currently, researchers cannot predict what mechanisms a cancer will to use to maintain the telomeres. "Cancers of the bones, stomach and soft tissues may be more efficient in activating ALT than telomerase pathways," says Karlseder, noting that indicators of ALT have also been observed in other cancer types. "We don't know why a tumor chooses one pathway over the other. All we know is that ALT may be switched on in response to telomerase inhibition, which means we must understand this pathway."
###
Marcela Raices, a former Salk postdoctoral fellow, now at University of California San Francisco, was co-first author with Lackner on the paper. Also contributing were Candy Haggblom of the Karlseder lab and Hugo Maruyama, a former graduate student in the lab, now at Osaka Dental University.
Funding for the study came from the National Institutes of Health, the Glenn Foundation for Medical Research, the Merieux Research Foundation, EMBO and the Blasker-Rose-Miah Fund.
About the Salk Institute for Biological Studies:
The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology, and related disciplines.
Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.
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Salk scientists open new window into how cancers override cellular growth controlsPublic release date: 21-Mar-2012 [ | E-mail | Share ]
Contact: Andy Hoang ahoang@salk.edu 619-861-5811 Salk Institute
Worm model of back-up telomere repair strategy could speed identification of anti-cancer drugs
LA JOLLA, CA----Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome.
Loss of telomeres forces cells out of the dividing game and into a growth arrest state called "senescence," but cancer cells evade this by employing an enzyme called telomerase to extend eroded telomeres.
If telomerase fails to activate, the tumor cells of about 10 percent of all human cancers have a back-up strategy to build serviceable telomeres and keep dividing. How that pathway, called ALT for alternative lengthening of telomeres, works is unclear, because researchers have had limited options to study it experimentally.
Now scientists at the at Salk Institute for Biological Studies have created roundworms that eke out an existence, and even manage to reproduce, relying solely on ALT to maintain telomeres. That study, published March 16 in EMBO Journal, provides a valuable tool to tinker with the ALT pathway and learn how to block it, with a goal of forcing tumor cells to senesce.
"These worms are the first multicellular organisms we can study in the laboratory that maintain their telomeres through the ALT pathway and not through telomerase," says Jan Karlseder, a professor in Salk's Molecular and Cell Biology Laboratory and the study's senior author. "Up to now we could only study ALT in cell lines derived from tumor cells. Now we can screen for compounds and genes that suppress or regulate ALT in a whole organism, which in worms is fairly easy to do."
The components of telomere-building pathways are prime targets for cancer researchers. "There is a huge interest in drugs that block telomerase, since 90 percent of cancers use it for telomere maintenance," says Daniel Lackner, a postdoctoral fellow in the Karlseder lab and one of the study's first authors. "But these drugs won't work for the 10 percent of cancers that use the ALT pathway. In fact, some evidence suggests that drugs targeting telomerase might actually increase ALT, making the need for ALT inhibitors more pressing."
The new study stems from a 2008 study from the Karlseder lab that was published in Cell. In that paper, they mutated a gene encoding a telomere-binding protein in roundworms. The resulting mutants displayed functional, but slightly scruffier-looking telomeres than those built by telomerase. That was a strong hint that when forced, worm cells, like human cells, can turn on the ALT pathway.
For the new study, the team pushed the mutant worms' survival capacity to the limit. This time they knocked out a second gene, telomerase itself, and found that these double mutants could reproduce continuously without undergoing senescence. Over the past 3 years a strain of double mutant worms has propagated for over 180 generations.
The group then used biochemistry to confirm that the worms depend totally on ALT for telomere maintenance. The telomeres of double mutants were more sloppily constructed than superior, telomerase-made caps and were similar in length and overall structure to chromosome caps displayed by human cancer cells that employ ALT.
The double mutant worms also contained wisps of telomeric DNA, called c-circles, that are unique by-products of ALT, further evidence that they were persisting via ALT.
Intriguingly, other investigators have reported that c-circles are present in the blood of human bone cancer patients and could potentially serve as a diagnostic for cancers that depend on the ALT rather than the telomerase pathway.
Although the worms are living long, species-wise, they are not quite prospering---- which is exactly what one would expect. The study reports that the double mutants have fewer offspring than normal worms, which is how roundworms exhibit "stress." And many have fused chromosomes, a likely outcome of having barely serviceable telomeres. But what counts is that the animals are viable, rely on ALT only, and their genome reflects aberrations seen in human tumor cells. In short, they are ready for analysis.
Currently, researchers cannot predict what mechanisms a cancer will to use to maintain the telomeres. "Cancers of the bones, stomach and soft tissues may be more efficient in activating ALT than telomerase pathways," says Karlseder, noting that indicators of ALT have also been observed in other cancer types. "We don't know why a tumor chooses one pathway over the other. All we know is that ALT may be switched on in response to telomerase inhibition, which means we must understand this pathway."
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Marcela Raices, a former Salk postdoctoral fellow, now at University of California San Francisco, was co-first author with Lackner on the paper. Also contributing were Candy Haggblom of the Karlseder lab and Hugo Maruyama, a former graduate student in the lab, now at Osaka Dental University.
Funding for the study came from the National Institutes of Health, the Glenn Foundation for Medical Research, the Merieux Research Foundation, EMBO and the Blasker-Rose-Miah Fund.
About the Salk Institute for Biological Studies:
The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology, and related disciplines.
Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.
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Public release date: 21-Mar-2012
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